解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Brain tumor initiating cells (BTICs) co-opt the neuronal high affinity glucose transporter, GLUT3, to withstand metabolic stress. We investigated another mechanism critical to brain metabolism, mitochondrial morphology, in BTICs. BTIC mitochondria were fragmented relative to non-BTIC tumor cell mitochondria, suggestin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3960
更新日期:2015-04-01 00:00:00
abstract::Remembering a past experience can, surprisingly, cause forgetting. Forgetting arises when other competing traces interfere with retrieval and inhibitory control mechanisms are engaged to suppress the distraction they cause. This form of forgetting is considered to be adaptive because it reduces future interference. Th...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3973
更新日期:2015-04-01 00:00:00
abstract::Human chromosome 16p11.2 microdeletion is the most common gene copy number variation in autism, but the synaptic pathophysiology caused by this mutation is largely unknown. Using a mouse with the same genetic deficiency, we found that metabotropic glutamate receptor 5 (mGluR5)-dependent synaptic plasticity and protein...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3911
更新日期:2015-02-01 00:00:00
abstract::Recording from neural networks at the resolution of action potentials is critical for understanding how information is processed in the brain. Here, we address this challenge by developing an organic material-based, ultraconformable, biocompatible and scalable neural interface array (the 'NeuroGrid') that can record b...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3905
更新日期:2015-02-01 00:00:00
abstract::Images are processed in the primary visual cortex by neurons that encode different stimulus orientations and spatial phases. In primates and carnivores, neighboring cortical neurons share similar orientation preferences, but spatial phases were thought to be randomly distributed. We discovered a columnar organization ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3878
更新日期:2015-01-01 00:00:00
abstract::We found that optogenetic burst stimulation of hippocampal dopaminergic fibers from midbrain neurons in mice exploring novel environments enhanced the reactivation of pyramidal cell assemblies during subsequent sleep/rest. When applied during spatial learning of new goal locations, dopaminergic photostimulation improv...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3843
更新日期:2014-12-01 00:00:00
abstract::Perturbations of astrocytes trigger neurodegeneration in several diseases, but the glial cell-intrinsic mechanisms that induce neurodegeneration remain poorly understood. We found that a protein complex of α2-Na/K ATPase and α-adducin was enriched in astrocytes expressing mutant superoxide dismutase 1 (SOD1), which ca...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3853
更新日期:2014-12-01 00:00:00
abstract::Neuregulin 1 type III is processed following regulated intramembrane proteolysis, which allows communication from the plasma membrane to the nucleus. We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3857
更新日期:2014-12-01 00:00:00
abstract::Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas and found a hierarchical ordering, with sensory and prefrontal ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3862
更新日期:2014-12-01 00:00:00
abstract::The launch of the US BRAIN and European Human Brain Projects coincides with growing international efforts toward transparency and increased access to publicly funded research in the neurosciences. The need for data-sharing standards and neuroinformatics infrastructure is more pressing than ever. However, 'big science'...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3838
更新日期:2014-11-01 00:00:00
abstract::Visual attention enhances the responses of visual neurons that encode the attended location. Several recent studies have shown that attention also decreases correlations between fluctuations in the responses of pairs of neurons (termed spike count correlation or r(SC)). These results are consistent with two hypotheses...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3835
更新日期:2014-11-01 00:00:00
abstract::Pain is fundamentally unpleasant, a feature that protects the organism by promoting motivation and learning. Relief of aversive states, including pain, is rewarding. The aversiveness of pain, as well as the reward from relief of pain, is encoded by brain reward/motivational mesocorticolimbic circuitry. In this Review,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3811
更新日期:2014-10-01 00:00:00
abstract::Age-related decreases in neural function result in part from alterations in synapses. To identify molecular defects that lead to such changes, we focused on the outer retina, in which synapses are markedly altered in old rodents and humans. We found that the serine/threonine kinase LKB1 and one of its substrates, AMPK...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3772
更新日期:2014-09-01 00:00:00
abstract::Sustained activity encoding visual working memory representations has been observed in several cortical areas of primates. Where along the visual pathways this activity emerges remains unknown. Here we show in macaques that sustained spiking activity encoding memorized visual motion directions is absent in direction-s...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3785
更新日期:2014-09-01 00:00:00
abstract::Olfaction has often been described as a ‘synthetic’ sense. A study now reveals a surprising capacity to resolve individual odorants in complex mixtures, with implications for how the nervous system recognizes objects. ...
journal_title:Nature neuroscience
pub_type: 评论,杂志文章
doi:10.1038/nn.3796
更新日期:2014-09-01 00:00:00
abstract::Sensorimotor integration is crucial to perception and motor control. How and where this process takes place in the brain is still largely unknown. Here we analyze the cerebellar contribution to sensorimotor integration in the whisker system of mice. We identify an area in the cerebellum where cortical sensory and moto...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3773
更新日期:2014-09-01 00:00:00
abstract::In Huntington's disease (HD), whether transneuronal spreading of mutant huntingtin (mHTT) occurs and its contribution to non-cell autonomous damage in brain networks is largely unknown. We found mHTT spreading in three different neural network models: human neurons integrated in the neural network of organotypic brain...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3761
更新日期:2014-08-01 00:00:00
abstract::Brain circuitry processes information by rapidly and selectively engaging functional neuronal networks. The dynamic formation of networks is often evident in rhythmically synchronized neuronal activity and tightly correlates with perceptual, cognitive and motor performances. But how synchronized neuronal activity cont...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3764
更新日期:2014-08-01 00:00:00
abstract::The identity of specific cell types in the nervous system is defined by the expression of neuron type-specific gene batteries. How the expression of such batteries is initiated during nervous system development has been under intensive study over the past few decades. However, comparatively little is known about how g...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3731
更新日期:2014-07-01 00:00:00
abstract::Neuronal migration disorders such as lissencephaly and subcortical band heterotopia are associated with epilepsy and intellectual disability. DCX, PAFAH1B1 and TUBA1A are mutated in these disorders; however, corresponding mouse mutants do not show heterotopic neurons in the neocortex. In contrast, spontaneously arisen...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3729
更新日期:2014-07-01 00:00:00
abstract::Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of aging-related neurodegenerative diseases, such as Parkinson's disease (PD). The basis of this vulnerability is not understood. To explore possible physiological determinants, we studied LC neurons using electrophysiological and optical approa...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3717
更新日期:2014-06-01 00:00:00
abstract::Dysfunction in sensory information processing is a hallmark of many neurological disorders, including autism spectrum disorders, schizophrenia and Rett syndrome (RTT). Using mouse models of RTT, a monogenic disorder caused by mutations in MECP2, we found that the large-scale loss of MeCP2 from forebrain GABAergic inte...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3710
更新日期:2014-06-01 00:00:00
abstract::Accurate optical reporting of electrical activity in genetically defined neuronal populations is a long-standing goal in neuroscience. We developed Accelerated Sensor of Action Potentials 1 (ASAP1), a voltage sensor design in which a circularly permuted green fluorescent protein is inserted in an extracellular loop of...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3709
更新日期:2014-06-01 00:00:00
abstract::Synaptic cadherin adhesion complexes are known to be key regulators of synapse plasticity. However, the molecular mechanisms that coordinate activity-induced modifications in cadherin localization and adhesion and the subsequent changes in synapse morphology and efficacy remain unknown. We demonstrate that the intrace...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3657
更新日期:2014-04-01 00:00:00
abstract::Olfactory representations are shaped by brain state and respiration. The interaction and circuit substrates of these influences are unclear. Granule cells (GCs) in the main olfactory bulb (MOB) are presumed to sculpt activity reaching the cortex via inhibition of mitral/tufted cells (MTs). GCs potentially make ensembl...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3669
更新日期:2014-04-01 00:00:00
abstract::Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs). We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs during synaptogenesis and in response to dopamine receptor Drd1 activation. LRRK2 interacted with PKA regulatory subunit IIβ (PKARIIβ). A lack...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3636
更新日期:2014-03-01 00:00:00
abstract::Every year in the United States, an estimated 500,000 babies are born preterm (before 37 completed weeks of gestation), and this number is rising, along with the recognition of brain injuries due to preterm delivery. A common underlying pathogenesis appears to be perinatal hypoxia induced by immature lung development,...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3604
更新日期:2014-03-01 00:00:00
abstract::The entorhinal cortex has been implicated in the early stages of Alzheimer's disease, which is characterized by changes in the tau protein and in the cleaved fragments of the amyloid precursor protein (APP). We used a high-resolution functional magnetic resonance imaging (fMRI) variant that can map metabolic defects i...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3606
更新日期:2014-02-01 00:00:00
abstract::Although the prefrontal cortex influences motivated behavior, its role in food intake remains unclear. Here, we demonstrate a role for D1-type dopamine receptor-expressing neurons in the medial prefrontal cortex (mPFC) in the regulation of feeding. Food intake increases activity in D1 neurons of the mPFC in mice, and ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3625
更新日期:2014-02-01 00:00:00
abstract::Individual differences in motor learning ability are widely acknowledged, yet little is known about the factors that underlie them. Here we explore whether movement-to-movement variability in motor output, a ubiquitous if often unwanted characteristic of motor performance, predicts motor learning ability. Surprisingly...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3616
更新日期:2014-02-01 00:00:00
abstract::Humans have ~400 intact odorant receptors, but each individual has a unique set of genetic variations that lead to variation in olfactory perception. We used a heterologous assay to determine how often genetic polymorphisms in odorant receptors alter receptor function. We identified agonists for 18 odorant receptors a...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3598
更新日期:2014-01-01 00:00:00
abstract::Memory is supported by a specific ensemble of neurons distributed in the brain that form a unique memory trace. We previously showed that neurons in the lateral amygdala expressing elevated levels of cAMP response-element binding protein are preferentially recruited into fear memory traces and are necessary for the ex...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3592
更新日期:2014-01-01 00:00:00
abstract::Neuroligins are postsynaptic cell adhesion molecules that are important for synaptic function through their trans-synaptic interaction with neurexins (NRXNs). The localization and synaptic effects of neuroligin-1 (NL-1, also called NLGN1) are specific to excitatory synapses with the capacity to enhance excitatory syna...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3601
更新日期:2014-01-01 00:00:00
abstract::Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3565
更新日期:2013-12-01 00:00:00
abstract::In this report we describe how common brain networks within the medial frontal cortex (MFC) facilitate adaptive behavioral control in rodents and humans. We demonstrate that after errors, low-frequency oscillations below 12 Hz are modulated over the midfrontal cortex in humans and within the prelimbic and anterior cin...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3549
更新日期:2013-12-01 00:00:00
abstract::Sleep can strengthen memory for emotional information, but whether emotional memories can be specifically targeted and modified during sleep is unknown. In human subjects who underwent olfactory contextual fear conditioning, re-exposure to the odorant context in slow-wave sleep promoted stimulus-specific fear extincti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3527
更新日期:2013-11-01 00:00:00
abstract::The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR...
journal_title:Nature neuroscience
pub_type: 杂志文章,评审
doi:10.1038/nn.3546
更新日期:2013-11-01 00:00:00
abstract::Relative quiescence and self renewal are defining features of adult stem cells, but their potential coordination remains unclear. Subependymal neural stem cells (NSCs) lacking cyclin-dependent kinase (CDK) inhibitor (CKI) 1a (p21) exhibit rapid expansion that is followed by their permanent loss later in life. Here we ...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3545
更新日期:2013-11-01 00:00:00
abstract::Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal lineage in mice (neurons, oligodendrocytes and astrocytes) results in attenuated severity of experimental autoimmune e...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3505
更新日期:2013-10-01 00:00:00
abstract::Fear renewal, a widely pursued model of post-traumatic stress disorder and phobias, refers to the context-specific relapse of conditioned fear after extinction. However, its molecular mechanisms are largely unknown. We found that renewal-inducing stimuli, generally believed to be insufficient to induce synaptic plasti...
journal_title:Nature neuroscience
pub_type: 杂志文章
doi:10.1038/nn.3491
更新日期:2013-10-01 00:00:00